AKT1 and cancer: Interestingly IFIT1 and IFIT3 genes are upregulated during cancer metastasis and invasion [54] and mediate their growth-promoting actions by complexing and phosphorylating Hsp90 and its client proteins PKC, EGFR, Akt, and p38 [54], together with our observation that miR193a-3p CM inhibits VEC growth as well as Akt and ERK1/2 phosphorylation, suggests that it may prevent MCF-7-driven angiogenic actions via this mechanism.