The restoration of functional dystrophin transcripts and protein following the excision of the exon 45-55 region has also been demonstrated in human DMD myoblasts with an exon 51 deletion (ΔEx51) mutation and a humanized DMD mouse model carrying the exon 45-deleted human dystrophin gene (hDMDΔ45/mdxD2) [130,155]. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.