DMD and Duchenne muscular dystrophy: Intriguingly, the utilization of SaCas9 and two sgRNAs targeting exons 47 and 58 leads to the formation of a hybrid exon 47-58 lacking their internal large region and the expression of 360 kDa dystrophin protein in human DMD myoblasts with ΔEx49-50, ΔEx50-52, ΔEx51-53, or ΔEx51-56 mutation [40].