For instance, mTORC2 (mTOR complex 2) was shown to affect and regulate glycolysis via c-Myc through a complex mechanism, involving histone deacetylases as well as FoxO1 (forkhead box O1) and FoxO3 (forkhead box O3) in GBM cells [41]. The gene discussed is FOXO3; the disease is glioblastoma.