Regarding potential interactions between CaSR- and cannabinoid-dependent pathways modulating [Ca2+]i, it is conceivable that WIN55212–2-dependent CB1R activation increases [Ca2+]i by augmenting CaSR-Gαq-dependent activation of PLC with the participation of CB1R-mediated Gi/o βγ release in neuroblastoma cells. This evidence concerns the gene HSPG2 and neuroblastoma.