NLRP3 and cancer: This neutrophil centered, interacting, multicomponent inflammation system consists of cancer cell synthesized G(M)-CSF [39,40,41], neutrophil extracellular traps (NETs) [42,43], activation of the NLRP3 inflammasome with consequent increases in MDSC functions [44,45,46], IL-1beta activation [47,48], normal mature neutrophils, and the higher NLR.