Sanus et al. performed an integrated genomic and transcriptomic unmatched analysis of 36 BMs from multiple primary tumor types (breast, lung, melanoma, and esophageal) which discovered novel candidates with potential roles in BM development, including significantly mutated genes DSC2, ST7, PIK3R1, and SMC5, in addition to DNA repair, ERBB–HER signaling, axon guidance, and protein kinase-A signaling pathways [68]. This evidence concerns the gene EGFR and neoplasm.