Shih et al. performed whole-exome sequencing of 73 BM–lung adenocarcinoma cases, and by identifying genes with more frequent copy-number alterations compared to a cohort of 503 primary lung adenocarcinomas, there were significantly higher amplifications frequencies of the BM for MYC (12% vs. 6%), YAP1 (7% vs. 0.8%), MMP13 (10% vs. 0.6%), and more deletions in CDKN2A/B (27% vs. 13%) [53]. Here, MMP13 is linked to lung adenocarcinoma.