A small study by Aljohani et al., involving whole genome sequencing of normal lung, primary tumor and the corresponding BM from 5 patients with progressive non-small cell lung cancer (NSCLC), revealed that primary tumors were associated with mutations in cell adhesion and motility, whereas BM acquired mutations in adaptive, cytoprotective genes such as KEAP-1, NRF2, and P300 [56]. This evidence concerns the gene KEAP1 and non-small cell lung carcinoma.