TOP2A and breast cancer: On the contrary, in Intestinal GC, the regulons of the active MRs, FOXM1 and TOP2A, resulted in strongly associated hallmark and GO, relative to the mitotic spindle assembly, G2/M checkpoint and E2F gene sets (Figure 2D) together with Kang doxorubicin resistance and the Farmer breast cancer cluster 2 (proliferation and 8q amplicon genes) gene set, respectively (Supplementary Materials Figure S15).