Previous studies revealed that increasing Piezo1 expression greatly enhanced the proliferation potentials of various tumor cell lines, including malignant melanoma, oral squamous cell carcinoma, and hepatocellular carcinoma (HCC), by affecting the protein kinase B (AKT)/mechanistic target of rapamycin (mTOR), MAPK, and transforming growth factor-β (TGF-β) pathways, respectively [37,40,53]. This evidence concerns the gene PIEZO1 and hepatocellular carcinoma.