Jiang et al. found that the expression levels of Bax, Bcl-2-associated agonist of cell death, caspase-3, and caspase-9, are significantly increased after Piezo1 is activated by tensile force, indicating that Piezo1 contributes to apoptosis in osteosarcoma cells [41]. The gene discussed is PIEZO1; the disease is osteosarcoma.