Most of the activated TFs are involved in cancer progression through the TIME (Figure 2C, Supplementary Figure S1), such as the NFκB family (NFKB1, NFKBIA, and RELA) and the STAT family (STAT1, STAT2, and STAT6), which are critical in M1 and M2 macrophage polarization [19]. Here, STAT6 is linked to cancer.