PCa is particularly resistant to the treatment with nucleoside analogs, such as 5-fluorouracil (5-FU) [23], an antimetabolite that inactivates the enzymatic activity of Thymidylate Synthase (TS), the key enzyme for de novo synthesis of 2′-deoxythymidine-5′-monophosphate (dTMP) [24]. This evidence concerns the gene TYMS and posterior cortical atrophy.