Inherited cancer predisposition, including hereditary syndromes (e.g., Lynch syndrome, familial adenomatous polyposis, Peutz-Jeghers syndrome, MUTYH-associated polyposis), and associated genes (e.g., MLH1, MSH2, MSH6, RPS20, APC, PTEN), accounts for about 13% of EOCRC [35]. Here, MSH2 is linked to Peutz-Jeghers syndrome.