TARBP2 might act as a tumor promoter in lung cancer [34], breast cancer [58], melanoma [59], hepatocellular carcinoma [60], adrenocortical carcinoma [61], and diffuse large B-cell lymphoma [62], but as a tumor suppressor in osteosarcoma [63] and Ewing sarcoma [64]. Here, TARBP2 is linked to osteosarcoma.