Interestingly in those clusters, we found some genes described to promote malignant tumor progression, such as FOXC1, which is considered as a main EMT inducer [58], KDM4B, an also well-known oncogene promoting dedifferentiation [59,60] or AREG, a growth factor capable of promoting hormone-independent proliferation [40]. This evidence concerns the gene KDM4B and neoplasm.