Using spatial transcriptomic analysis of the ROIs we identified 162 genes downregulated (e.g., HLA-B, HLA-C, CDH1, MIF, RELA and MDM2) and 69 upregulated (e.g., FZD7, FGFR1, FGF7, FGFR1, TGFBR1, TCF7, FLNA, FLNAC, JAM 3 and CSFR1) in TAS as compared to tumor epithelium. The gene discussed is RELA; the disease is neoplasm.