TGFB1 and melanoma: Among many redox-sensitive signals, we previously demonstrated in a mouse melanoma model that mtROS signaling in metastatic progenitor comprises the activation of the TGFβ pathway at the level of src kinase (Y416 phosphorylation) directly within mitochondria [5], thus bypassing the need of TGFβ to bind to the TGFβ receptor for pathway activation.