Therefore, we further divided PV patients with JAK2 mutation into high burden group (mutational burden ≥ 50%, n = 16) and low burden group (mutational burden < 50%, n = 8), and the comparison revealed that WBC levels were significantly higher in the JAK2 high burden group than in the low burden group and the unmutated group (p = 0.01; p = 0.014; Figure 3E). The gene discussed is JAK2; the disease is acquired polycythemia vera.