In this study, Cer(d18:2/22:6-2OH(7S, 17S)), SM(d18:0/PGF1α), CerP(d18:1/16:0) and octadec-13-enoylcarnitine were selected as biomarkers of poor prognosis in PV patients by risk stratification and ROC curves. This evidence concerns the gene ABCA1 and acquired polycythemia vera.