Yonemori et al. [45] found that ProGRP was a significant predictive factor for the first failure event due to BM (HR: 12.5, 95% CI: 2.00–77.9, p = 0.007) and the overall incidence of BM (HR: 5.89, 95% CI: 1.25–27.7, p = 0.025) in LS-SCLC. The gene discussed is GRP; the disease is small cell lung carcinoma.