EGFR and esophageal squamous cell carcinoma: Although we were not able to immunohistochemically evidence a correlation between activation of EGFR downstream signaling (detected by using phosphor-specific antibodies against p44/42MAP kinase, p38 MAP kinase, and Akt) and invasion-associated accumulation of Lng2, a relation to EGFR expression could be proven by others for esophageal SCC in situ and in vitro [95,96].