When analyzing GOIs’ expression between controls and cancer patients in the division based on the Youden’s index regarding BMI, the expression of VEGFA was significantly higher in malignant lesion samples in the group with a BMI ≤ 29 (p < 0.0001) and EPAS1 in controls in the group BMI > 29 (p = 0.0084). The gene discussed is EPAS1; the disease is cancer.