Among the former, WNT/CTNNTB1 somatic mutation has the soundest evidence to promote HCC immune escape [15], along with the expression of multiple immune checkpoints such as lymphocyte-activation gene 3 (LAG-3), fibrinogen-like protein1(FGL1), T-cell immunoreceptor with Ig and ITIM domains (TIGIT)-nectin cell adhesion molecule 2 (NECTIN2) and CD 155. Here, NECTIN2 is linked to hepatocellular carcinoma.