Bone metastasis is usually associated with the molecules related to bone formation and absorption, such as receptor activator of nuclear factor-κB ligand (RANK-L), parathyroid hormone-related protein (PTHrP), and tumor necrosis factor-alpha (TNF- α), and due to the suitable bone microenvironment, tumor cells can easily settle and proliferate in bone [12]. The gene discussed is TNF; the disease is neoplasm.