At initial diagnosis in the nodular sclerosis subtype, we identified 6 upregulated genes (TNFSF11, KLRG2, C5, NCAM1, TNFRSF17, TLR2), and 18 downregulated genes (STAT6, STAT3, CXCR3, CD3D, STAT5A, CD99, PTPN2, SOCS3, ITGAX, JAK3, BAX, LAG3, CD79A, TGFBI, CD45RO, LGALS1, HLA-DRB1, MS4A1) (p < 0.05) in r/r patients as compared to non-r/r patients (Figure 2a). This evidence concerns the gene LAG3 and Hodgkins lymphoma.