ICOS and Hodgkins lymphoma: Comparison between paired diagnostic and relapse samples in the nodular sclerosis subtype showed upregulation of immunosuppressive cytokines such as LGALS1 (encoding for galectin-1) and TGFB1 (encoding for TGF-β) and downregulation of the T-cell costimulatory receptor ICOS at relapse, reflecting some measure of immune-evasion.