CD274 and cancer: Nevertheless, multiplexed spatial profiling, when using just 2–3 parameters (such as in T cell activation states, density, and PD-1/PD-L1 proximity) has already been demonstrated to be superior to the combined evaluation of TMB, PD-L1, HLA, and GEP in predicting anti-PD-1/PD-L1 benefits in other cancer types [56].