CD8A and breast cancer: On the contrary, in a preclinical hepatic metastasis model, TAMs could induce a FAS-L-mediated direct killing of nearby CD8+ T cells [155], an interaction which is associated with a significant systemic depletion of T cells that correlate with reduced intratumoral cancer-cell specific T cells clones and T cell diversity—as was evaluated in a cohort that included patients with BC [155].