Nrf2 signaling orchestrates a robust and varied response to the abundant mitochondrial production of ROS in CLL cells, especially promoting the overexpression of GCL modulatory and catalytic subunits contributes to maintaining a high content of GSH [89] as well as the upregulation of HO-1, a positive regulator of transcription factor A, mitochondrial (TFAM), which stimulates mitochondrial biogenesis as a mechanism compensating for the ROS-induced damage and decreased energy production of mitochondria [90]. Here, NFE2L2 is linked to B-cell chronic lymphocytic leukemia.