NFE2L2 and B-cell chronic lymphocytic leukemia: Nrf2 is a pivotal transcription factor composed of seven conserved Nrf2-ECH homology (Neh) domains, which, in response to oxidative stress and toxic insults, induces the expression of a wide variety of proteins actively involved in the antioxidant response [87,88], as exemplified in Figure 3A. In CLL, it has been demonstrated that Nrf2 is highly expressed and is key to survival, as corroborated by studies highlighting the cytotoxic effects of electrophilic and antioxidant compounds targeting Nrf2 signaling [26].