ACTA1 and cancer: Özdemir et al. depleted α-smooth muscle actin (α-SMA)-positive CAFs in GEMM, because α-SMA-positive CAFs had been considered as activated CAFs through the tumor–stromal interactions, with possible expectation that the depletion of α-SMA-positive CAFs would reduce the fibrosis, as well as stromal volume, and deplete the cancer-promoting activities, resulting in improved prognosis.