Li et al. identified four CAF clusters in human gastric cancer and found that distinct CAF subtypes interact with different immune cell populations to form immunosuppressive TME: iCAF induces lymphocyte recruitment and regulates CD8+ and PD-1+ T cells by secreting IL-6 and CXCL12, while periostin expressing another CAF subtype recruits M2 macrophages. The gene discussed is POSTN; the disease is gastric cancer.