In line with this, we have investigated the tumor–stromal interactions between PDAC cells and CAFs in GEMM and found that PDAC cells and CAFs produced and secreted the same kinds of CXC chemokines (ligands of the CXC chemokine receptor 2 (CXCR2)), and CAFs enhanced the PDAC cell invasion, while PDAC cells enhanced the CAF migration, suggesting that PDAC cells and CAFs might attract each other and contribute to their invasion and metastasis [31,32]. Here, CXCR2 is linked to neoplasm.