HMGB1 and central nervous system cancer: Figure 6a displays a remarkable association between HMGB1 expression and stromal score, including GBMLGG (Glioma), KIPAN, and KIRC. As shown in Figure 6b,c, high expression of HMGB1 has a significantly positive correlation with the immune-score as well as the estimate score (also known as tumor purity) in KIPAN, but a negative correlation in GBMLGG and LUSC.