HMGB1 showed a positive association with CDK1 (R = 0.51), SSRP1 (R = 0.57), H2AFV (R = 0.53), and HMGB2 (R = 0.57) genes in several cancer types and these data were visualized as a heatmap (Figure 7c,d). The gene discussed is HMGB2; the disease is cancer.