Moreover, we used TCGA multicancer (PANCAN, N = 10,535, G = 60,499), from which we obtained the ENSG00000189403 (HMGB1), and the samples derived from the Cancer Peripheral Blood function to explore the how genetic variation in HMGB1 is related with both clinical prognosis in different types of cancer and with microsatellite instability. This evidence concerns the gene HMGB1 and cancer.