Indeed, targeting key kinases engaged in the DDR and DNA repair pathways, such as ATM/ATR, CHK1/CHK2, WEE1, DNA-PKcs and PARP1, appears to be a promising approach for improving the radiosensitivity to CRC with further insight into the molecular mechanisms underlying IR-induced DNA damage recognition and repair. Here, CHEK2 is linked to colorectal carcinoma.