In addition, the study of the NEU-1 expression level in 26 different mouse colon adenocarcinoma cells which had different metastatic potential showed that the NEU-1 mRNA was less expressed, and its activity levels were lower in the highly metastatic NL17 and NL22 cells when they were compared to the NL4 and NL44 cell lines with a low metastatic potential [39]. The gene discussed is NEU1; the disease is colon adenocarcinoma.