NSD1 and acute myeloid leukemia: The first mention of NSD1 role in tumorigenesis comes from the discovery in childhood acute myeloid leukemia (AML) of a translocation at t (5;11) (q35;p15.5) encoding a chimeric protein encompassing the carboxyl terminal of NSD1 that retains among other the catalytic SET domain fused to the FG-repeat domain of the nucleoporin protein NUP98, a component of the nuclear core complex.