The exemplary genes from HIF-1- related metabolic pathways are shown in Figure 5B. Moreover, several genes belonging to the category “Transcriptional misregulation in cancer” coding for proteins important for cancer progression had higher expression at 5% oxygen, including MMP9, BCL6, RARA, MAF, ID2 and PROM1 (Figure 5B). The gene discussed is RARA; the disease is cancer.