Studies in hepatocellular carcinoma also showed that transcriptional expression of the Angpt2 promoter was directly targeted by FOXC2 and that Angpt2 knockdown abolished FOXC2-facilitated angiogenesis and tumor growth, suggesting that FOXC2 promotes tumor progression via regulation of Angpt2 [30]. This evidence concerns the gene ANGPT2 and hepatocellular carcinoma.