BRCA1 and ovarian cancer: To investigate the potential function(s) of FOXC2 in ovarian cancer and the possible synergism or reliance on genes that are frequently altered in ovarian cancers, such as myc, Akt, Kras, and Brca1, ten genetically defined primary and metastatic mouse ovarian cancer cell lines [56,57] were retrovirally transduced with human FOXC2 or green fluorescent protein (GFP) control (Figure 1A).