ACE and hepatocellular carcinoma: Based on the multivariate Cox proportional hazards model, BCLC stage C (hazard ratio [HR], 1.816, 95% CI 1.331–2.477, p  <  0.001), ALBI grade II/III (HR, 1.484, 95% CI 1.060–2.079, p  =  0.022), extrahepatic spread (HR, 1.976, 95% CI 1.405–2.780, p < 0.001), baseline AFP level ≥ 90 (HR, 1.433, 95% CI 1.021–2.012, p = 0.038), baseline DCP level ≥ 500 (HR, 1.605, 95% CI 1.135–2.270, p < 0.001), a FIB-4 index ≥ 4 (HR, 1.522, 95% CI 1.079–2.146, p  =  0.017), and the achievement of SVR (HR, 0.464, 95% CI 0.294–0.732, p  =  0.001) were independent risk factors for HCV-related HCC (Table 2).