Dox alone or Dox + antibiotic administration reduced tumor proliferation, as determined by Ki67 immunoreactivity (Figure 1E), and increased apoptosis, as determined by cleaved caspase 3 immunoreactivity (Figure 1F), suggesting that antibiotics did not negatively affect Dox efficacy on primary tumor proliferation or apoptosis. This evidence concerns the gene CASP3 and neoplasm.