To evaluate the effects of the pharmacological blockade of both p38α and MEK/ERK on the c-MYC protein levels in vivo, we used the azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-associated-carcinoma murine model, which is considered a highly reproducible and reliable CRC model [49]. This evidence concerns the gene MYC and colorectal carcinoma.