MYC and colorectal carcinoma: To this end, we analyzed the c-MYC protein levels upon treatment with classical p38α and MEK chemical inhibitors (SB202190 and PD98059, respectively) in the CRC cell lines (HT29, HCT116, and Caco2 cells) carrying different genetic backgrounds and that were representative of the chromosomal instability (CIN) and microsatellite instability (MIN) CRC phenotypes, as indicated in Figure 1a (left panel).