Interference with the Snail–miR-146a–β-catenin loop by inhibiting MEK or Wnt activity reduces the symmetrical division of CRCSCs, attenuating the tumorigenicity, and the high-Snail–low-NUMB profile has been correlated with cetuximab resistance and a poorer prognosis in colorectal cancer [110]. This evidence concerns the gene MAP2K7 and colorectal cancer.