NcRNAs play crucial roles in modulating the resistance to molecular therapies in CRC, including oncogenes and tumor suppressors such as miRNAs, lncRNAs and circRNAs, based on miRNA–mRNA, lncRNA–miRNA–mRNA or circRNA–miRNA–mRNA regulatory networks through the EGFR signaling pathway, the RAS signaling pathway and the PI3K/AKT signaling pathway (Figure 5). The gene discussed is PIK3CA; the disease is colorectal carcinoma.