Pagès et al. could demonstrate in a large cohort of stage I–III colon cancer patients that an increased infiltration of CD3+ and cytotoxic CD8+ T-cells (Immunoscore high) is associated with a lower risk of disease recurrence and longer overall survival compared to those patients whose tumors exhibit a decreased CD3+/CD8+ density Immunoscore low) independent of age, T or N stages and MSI status. Here, CD8A is linked to malignant colon neoplasm.