However, considering that the prediction of IDH mutation in gliomas has shown better performance, achieving 87–92% accuracy in distinguishing IDH mutant gliomas from IDH wild-type tumors using only conventional MRI [26,27], although this classification task is a more difficult task than MGMT methylation prediction because of the class imbalance of IDH mutation, it might be more plausible that MGMT mutations may not actually be reflected by a noticeable change in mpMRI. This evidence concerns the gene MGMT and central nervous system cancer.