GZMB and neoplasm: Therefore, we also evaluated the effects of Q702 on key moderators of cell-mediated immunity, including IFN-γ and granzyme B. When T cells or NK cells from tumor samples were stimulated in vitro with phorbol 12-myristate 13-acetate (PMA) and ionomycin, the proportion of IFN-γ-producing CD4 T cells significantly increased in the Q702 treatment group.