IL1B and neoplasm: This result suggests IL-1 inhibition by MLX01, VX765, and Anakinra may inhibit tumour-cell-induced osteoclastic bone resorption as seen at earlier timepoints, as has previously been shown following administration of Anakinra [12], helping prevent the vicious cycle of bone metastasis [22], and reducing bone turnover/osteoblast genesis resulting in decreased tumour cell growth in the bone.