Overexpression of IL1β significantly increased E0771 and Py8119 cell migration and invasion towards OB1 cells (migration p = 0.0026, p = 0.0094; invasion p = 0.0007, p = 0.0001, respectively) (Figure 2C,D), suggesting that tumour derived IL1β enhances the functional properties of breast cancer cells enabling migration and invasion towards bone. The gene discussed is IL1B; the disease is breast cancer.