Interestingly, bioluminescence imaging showed that when tumours did grow in the bone and multiple organs, their volume was not altered following treatment with any inhibitors tested, suggesting that inhibition of the IL1β signalling pathway prevents the initial stages of metastatic outgrowth of disseminated tumour cells in the bone but does not slow down the growth of established tumours in this site (Figure 3D,F,K,M and Figure S6D,F). Here, IL1B is linked to neoplasm.