In order to determine whether SIPA1 can affect metastasis by regulating the EMT process through lncRNA, high-throughput RNA sequencing was performed on MDA-MB-231 and MDA-MB-231/SH-SIPA1 breast cancer cells with knockdown of SIPA1 expression level, and RNA expression data of the two cells were obtained. The gene discussed is SIPA1; the disease is breast carcinoma.