Under a normal environment, tumor cells enhance metastasis via the EMT process, which is accompanied by the transformation of immotile epithelial cells into motile mesenchymal cells, with downregulation of epithelial markers (such as E-cadherin) and upregulation of mesenchymal markers (such as vimentin and N-cadherin) [48,49]. Here, CDH1 is linked to neoplasm.