DKK1 and hepatocellular carcinoma: Recent studies have shown that serum levels of Dickkopf-related protein 1 (DKK-1), a circulating intermediate of the Wnt/β-catenin signaling cascade that is overexpressed in HCC, are associated with poor clinical outcome, making it an interesting biomarker candidate for HCC treatment monitoring [11,12,13,14,15].