DKK1 and hepatocellular carcinoma: Moreover, patients with HCC lesions >5 cm (n = 29) showed significantly higher DKK-1 serum levels compared to patients with lesions <5 cm (n = 68) (1261 [range, 403–4515] pg/mL versus 838 [range, 199–2263] pg/mL; p < 0.001).