In addition, a monoclonal antibody directed against the 78 kDa glucose-regulated protein (GRP78)—an Ag highly expressed by breast tumor cells [156]—and isolated from a gastric cancer patient [155] was shown to be able to directly kill cancer cells by cellular lipotoxicity involving intracellular lipids, cholesterylester, and triglycerides accumulation and leading to cell apoptosis. This evidence concerns the gene HSPA5 and cancer.