These discordant results may be linked to the phenotypic and functional heterogeneity of the tumors ASCs infiltrate, as well as to methodological issues linked to the detection of ASCs, which range from a simple morphological identification, IHC/IF analysis with different markers like CD138 and IRF4, to computational analysis of ASC gene signature score from tumor bulk RNA-seq data using diverse algorithms. The gene discussed is SDC1; the disease is neoplasm.