In a model of HER2/neu+ breast cancer cells opsonized by anti-HER2 IgG1 Ab, Matlung et al., indeed demonstrated that this cytotoxicity was not dependent on lytic granule release and involved an active mechanic destruction of the target cell plasma membrane, leading to a form of immune cell-mediated necrotic type of cell death referred to as trogoptosis [109]. The gene discussed is ERBB2; the disease is breast cancer.