In addition, a monoclonal antibody directed against the 78 kDa glucose-regulated protein (GRP78)—an Ag highly expressed by breast tumor cells [156]—and isolated from a gastric cancer patient [155] was shown to be able to directly kill cancer cells by cellular lipotoxicity involving intracellular lipids, cholesterylester, and triglycerides accumulation and leading to cell apoptosis. The gene discussed is HSPA5; the disease is breast neoplasm.