Interestingly, PCs in human lung cancers can express EBI3, a component of IL-27 and IL-35 heterodimers [173], and IL-10 [9,10,11] a cytokine with both tumor-promoting properties through inhibition of tumor Ag presentation [12,13] and tumor-inhibiting activities through anti-angiogenic functions via down-regulation of VEGF, IL-1b, TNF-α, IL-6, and MMP-9 [174]). This evidence concerns the gene VEGFA and neoplasm.