In particular, the antineoplastic effect of statins on prostate cancer cells was thought to occur through: (1) cholesterol-mediated mechanisms (whereby cholesterol-rich lipid rafts in cell membrane are disrupted, affecting signal transduction); and (2) non-cholesterol-mediated mechanisms (affecting other signalling pathways such as Ras and Rho) [11]. The gene discussed is RHO; the disease is prostate carcinoma.