In LKB1-deficient lung cancer, pleomorphic adenoma gene 1 (PLAG1) mediates the upregulation of a glutaminolysis enzyme, glutamate dehydrogenase 1 (GDH1), and calcium/calmodulin-dependent protein kinase kinase 2 bound to AMP-activated protein kinase (AMPK). Here, STK11 is linked to lung carcinoma.