Looking at comparable clinical outcomes of ALEX and BFAST studies, which allocated ALK-mutated NSCLC patients to alectinib treatment based on tissue or liquid biopsy results, respectively, it can be deduced that also ALK rearrangement in ctDNA can be considered a valid approach to select patients suitable for alectinib in first-line therapy [27,84,85]. The gene discussed is ALK; the disease is non-small cell lung carcinoma.