TSC2 and non-small cell lung carcinoma: Contrary to what was elaborated earlier on the role of EZH2 in cisplatin resistance, in a recent study, the authors showed that long non-coding RNA ACTA2-AS1 inhibited the cisplatin resistance of NSCLC cell lines through suppressing TSC2 expression by recruiting EZH2 to the TSC2 gene promoter [139].