FLT3 and acute myeloid leukemia: Furthermore, in the context of post-alloSCT treatment, the maintenance with Sorafenib, a multitargeted tyrosine kinase inhibitor, has proved to reduce the risk of relapse and death in FLT3-ITD-positive AML patients in CR (HR relapse or death 0.39, log-rank p = 0.013) [51].