Research conducted by Ting-ting Wang clarified that the JAK2/STAT3 signaling pathway is related to neutrophils in tumor immunosuppression, and it was shown that TANs were activated by GM-CSF and the induced high-level expression of the immunosuppressive molecule PD-L1 by the activation of the JAK2/STAT3 signaling pathway [39]. The gene discussed is CD274; the disease is neoplasm.