To gain insight into the molecular mechanisms that mediate the biological effects of endothelial cells on PCa cells, we identified factors expressed and secreted into the CM by HUVEC cells and found that CCL2, IL-6, CXCL1, FGF2 and HGF were central nodes within the entire network of endothelial cell-secreted factors. Here, IL6 is linked to posterior cortical atrophy.