In PC-3 cells, HUVEC-CM stimulated the secretion of factors related to inflammation (IL-10 and Il-22), chemokines (MIP3A and CXCL5) and factors associated with angiogenesis (THBS1 and ANG-2) that are related to the promotion of cell survival, proliferation, enhancing the growth of xenografted tumor cells, tumor vascularization and invasion in vivo [38,39]. The gene discussed is ANGPT2; the disease is neoplasm.